个人简介

      2003年7月毕业于西北大学化学系化学基地班，获得理学学士学位。2009年7月毕业于中国科学院上海有机化学研究所，获得理学博士学位，导师伍贻康研究员。2010年至2015年于印第安纳大学-普渡大学联合分校从事博士后研究工作，合作导师Lei Li教授。2015年8月年进入威廉希尔体育app官网工作。主持国家自然科学基金青年基金项目1项，陕西省自然科学基础研究计划面上项目2项。到目前为止，在JACS，OL，JOC，Chem Eur J等学术期刊上发表学术论文30余篇。

      目前的研究兴趣为过渡金属催化，DNA-过渡金属杂合催化剂的设计合成及催化性能。

代表性论文

17.Han, J.; Zhang, J.; Zhang, W.; Gao, Z.; Xu, L. *; Jian, Y.* “On water” catalytic Aldol reaction between isatins and acetophenones: interfacial hydrogen bonding and enamine mechanism. J. Org. Chem., 2019, 84(12), 7642-7651.

16.Wang, Y.; Jian, Y.*; Wu, Y.; Sun, H.; Zhang, G.; Zhang, W.; Gao, Z. * “Organometallic titanocene complex as highly efficient bifunctional catalyst for intramolecular Mannich reaction”. Appl. Organomet. Chem., 2019, 33:e4925.

15. Su, J.; Zhang, K.; Zhuang, M.; Ma, F.; Zhang, W.; Sun, H.; Zhang, G.; Jian, Y. *; Gao, Z.* “One-Pot Synthesis of Indoles from aniline and α, β-ynones through Iodine-Mediated transition metal free tandem aza-Michael addition/C-H functionalization.” Asian J. Org. Chem. 2019, 8, 482-486.

14.Zheng, S.; Jian, Y.*; Xu, S.; Wu, Y.; Sun, H.; Zhang, G.; Zhang W.; Gao, Z. * “N-Donor ligand activation of titanocene for the Biginelli reaction via the imine mechanism”. RSC Adv., 2018, 8: 8657-8661.

13.Jian, Y.; Maximowitsch, E.; Liu, D.; Adhikari, S.; Li, L.*; Domratcheva, T.* Indications of 5′ to 3′ Interbase Electron Transfer as the First Step of Pyrimidine Dimer Formation Probed by a Dinucleotide Analog”. Chem. Eur. J. 2017, 23, 7526-7537.

12.Jian, Y.; Lin, G.; Chomicz, L.;  Li, L*. “Reactivity of Damaged Pyrimidines: Formation of a Schiff base intermediate at the glycosidic bond of saturated dihydrouridine”, J. Am. Chem. Soc. 2015, 137 (9), 3318-3329.

11.Jian, Y.; Ames, D. M.; Ouyang, H.; Li, L*. “Photochemical reactions of microcrystalline thymidine”, Org. Lett. 2015, 17(4), 824-827.

10.Lin, G.; Jian, Y.; Ouyang, H.;  Li, L*. “An unexpected deamination reaction after hydrolysis of the pyrimidine (6-4) pyrimidone photoproduct” Org. Lett., 2014, 16(19), 5076-5079.

9.Lin, G.; Jian, Y.; Dria, K. J.; Long, E. C.; Li, L*. “Reactivity of Damaged Pyrimidines: DNA Cleavage via Hemiaminal Formation at the C4 Positions of the Saturated Thymine of Spore Photoproduct and Dihydrouridine”, J. Am. Chem. Soc., 2014, 136, 12938-1294.

8.Ames, D. M.; Lin, G.; Jian, Y.; Cadet, J.; Li, L*. “Unusually large deuterium discrimination during spore photoproduct formation”, J. Org. Chem., 2014, 79 (11), 4843–4851. (chosen as a featured article by editor)

7.Singh, I.; Jian, Y.; Li, L. *; Georgiadis, M. M*. “The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition” Acta Cryst., 2014, D70, 752–759.

6.Jian, Y.; Li, L*. “Chemical syntheses of oligodeoxyribonucleotides containing spore photoproduct - a special thymine dimer” J. Org. Chem. 2013, 78, 3021-3029.

5.Yang, L.; Lin, G.; Nelson, R. S; Jian, Y.; Telser, J.; Li, L*. “Mechanistic Studies of the Spore Photoproduct Lyase via a Single Cysteine Mutation”, Biochemistry, 2012, 51, 7173–7188.

4.Jian, Y.-J.; Wu, Y.-K*. “The enantioselective total synthesis of nemotin”. Org. Biomol. Chem. 2010, 8, 811-821.

3.Jian, Y.-J.; Wu, Y.-K*. “Synthesis of the structure proposed for the natural allenic antibiotic scorodonin”. Org. Biomol. Chem. 2010, 8(8), 1905-9.

2.Jian, Y.-J.; Tang, C.-J.; Wu, Y.-K*. ‘‘Enantioselective Total Synthesis of Phomallenic Acid C”. J. Org. Chem. 2007,  72, 4851-4855.

1.Jian, Y.-J.; Wu, Y.-K. *; Li, L.; Lu, J*. ‘‘An expeditious route to the antipode of harzialactone A”. Tetrahedron: Asymmetry 2005, 16, 2649-2651.