个人简介

2009年7月于清华大学化学系获理学博士学位。现为陕师大威廉希尔体育app官网教授，分析化学/化学生物学专业博士生导师。2015年度“陕西省青年科技新星”；2016年获得国家基金委“优秀青年科学基金”资助；2020年获陕西青年科技奖；现担任Wiley出版社ChemistrySelect期刊编委。主要研究兴趣为：（1）生化分析与分子诊断；（2）功能材料表界面传感；（3）单分子与单颗粒分析。先后主持国家自然科学基金等省部级以上项目10项，获陕西省及河北省科学技术奖励3项。作为通讯作者在Angew. Chem. Int. Ed., Nano Lett., Chem. Sci.,Anal. Chem.,Adv. Funct. Mater.等发表论文70余篇。

因科研工作需要，课题组常年招聘师资博士后，特别优秀者可直接申报副教授岗位，陕师大正处于快速发展时期，人才引进力度大，待遇优厚，具体情况可邮件联系。热忱欢迎从事微流控芯片分析、功能材料与器件、分子诊断、纳米生物技术等相关领域的同仁加盟合作。

代表性成果

Desheng Chen^†, Xiaobo Zhang^†, Liping Zhu, Chenghui Liu*, Zhengping Li*. All on Size-Coded Single Bead Set: Modular Enrich-Amplify-Amplify Strategy for Attomolar Level Multi-Immunoassay.Chem. Sci.,2022, DOI: 10.1039/D1SC07048G.

Xiaoling Liu*, Xinyue Kang, Chao Lei, Wei Ren, Chenghui Liu*. Programming the trans-cleavage activity of CRISPR-Cas13a by single-strand DNA blocker and its biosensing application.Anal. Chem.,2022, DOI: 10.1021/acs.analchem.1c05124.

Qinya Feng, Wenjiao Fan, Wei Ren*, Chenghui Liu*. Recent Advances in Exosome Analysis Assisted by Functional Nucleic Acid-based Signal Amplification Technologies.Trends Anal. Chem.,2022, 149, 116549.

Wenjiao Fan, Pihua Han, Qinya Feng, Yuanyuan Sun, Wei Ren, Thomas Lawson, and Chenghui Liu*. Nucleic Acid Substrate-Independent DNA Polymerization on the Exosome Membrane: A Mechanism Study and Application in Exosome Analysis.Anal. Chem.,2022, 94, 2172-2179.

Lijun Zhang, Wenjiao Fan, Dailu Jia, Qinya Feng, Wei Ren, Chenghui Liu*. Microchamber-Free Digital Flow Cytometric Analysis of T4 Polynucleotide Kinase Phosphatase Based on Single Enzyme-to-Single Bead Space-Confined Reaction. Anal. Chem., 2021, 93, 14828-14836.

Xiaohui Lu^†, Chen Hu^†, Dailu Jia, Wenjiao Fan, Wei Ren*, Chenghui Liu*. Amplification-Free and Mix-and-Read Analysis of Multiplexed MicroRNAs on a Single Plasmonic Microbead.Nano Lett.,2021, 21, 6718-6724.

Yan Qi, Yuqing Zhai, Wenjiao Fan, Wei Ren, Zhengping Li, Chenghui Liu*. Click Chemistry-Actuated Digital DNA Walker Confined on a Single Particle toward the Absolute MicroRNA Quantification.Anal. Chem.,2021, 93, 1620-1626.

Gaoting Wang, Weimin Tian, Xiaoling Liu*, Wei Ren, Chenghui Liu*. A new CRISPR-derived microRNA sensing mechanism based on Cas12a self-powered and rolling circle transcription (RCT)-unleashed real-time crRNA recruiting.Anal. Chem.,2020, 92, 6702-6708.

Xiaohui Lu, Wei Ren, Chen Hu, Chenghui Liu*, Zhengping Li*. Plasmon-Enhanced SERS Mapping Concentrated on a Single Bead for the Ultrasensitive and Multiplexed Immunoassay. Anal. Chem., 2020, 92, 12387-12393.

Zhenhao Zhang, Dandan Yang, Weimin Tian, Yan Qi, Wei Ren, Zhengping Li, Chenghui Liu*. Facile Clamp-Assisted Ligation Strategy for Direct Discrimination and Background-Free Quantification of Site-Specific 5‑Formylcytosine. Anal. Chem., 2020, 92, 3477-3482.

Hui Tian, Wenhan Zhao, Xiaolong Liu, Chenghui Liu*, Niancai Peng*. An integrated single microbead-arrayed μ-fluidic platform for the automated detection of multiplexed biomarkers.ACS Sens.,2020, 5, 798-806.

Ya Li^†, Dailu Jia^†, Wei Ren*, Feng Shi, Chenghui Liu*. A Versatile Photoinduced Electron Transfer-Based Upconversion Fluorescent Biosensing Platform for the Detection of Disease Biomarkers and Nerve Agent.Adv. Funct. Mater.,2019, 29, 1903191.

Liping Zhu, Desheng Chen, Xiaohui Lu, Yan Qi, Pan He, Chenghui Liu,* Zhengping Li. An Ultrasensitive Flow Cytometric Immunoassay Based on Bead Surface-Initiated Template-Free DNA Extension.Chem. Sci.,2018, 9, 6605-6613.

Wenjiao Fan, Yan Qi, Liying Qiu, Pan He, Chenghui Liu,* Zhengping Li. Click Chemical Ligation-Initiated On-Bead DNA Polymerization for the Sensitive Flow Cytometric Detection of 3´-Terminal 2´-O-Methylated Plant MicroRNA.Anal. Chem.,2018, 90, 5390-5397.

Yueying Sun, Yuanyuan Sun, Weimin Tian, Chenghui Liu,* Kejian Gao, Zhengping Li.* A novel restriction endonuclease GlaI for rapid and highly sensitive detection of DNA methylation coupled with isothermal exponential amplification reaction.Chem. Sci.,2018, 9, 1344-1351.