个人简介

2003年7月于河北大学获理学学士学位；2006 年7月于河北大学获理学硕士学位；2010年7月于中国科学院化学研究所获理学博士学位。2010年度中国科学院院长优秀奖。曾获得2011年度中国科学院优秀博士学位论文。至今在J. Am. Chem. Soc., Nat. Protoc., Adv. Mater., Anal. Chem., Chem. Commun., 等国际刊物发表文章40余篇。讲授课程：化学分析，仪器分析，现代分析化学（双语），无机及分析化学，化学生物学。

研究方向：

1.干细胞识别与分离新方法

2. 点击化学激活的荧光小分子探针

3. 活体成像生物发光、荧光探针设计与合成

研究手段：

有机合成；点击化学；磁性分离；代谢标记；静电纺丝

实验室：致知楼1525；办公室：致知楼1564.

发表论文

2022

1. Wei Tang, Wenbo Ma, Tianjiao Meng, Wanying Han, Chenghui Liu*, and Xinrui Duan*, Chemically Enhanced Live Probiotic for In Vivo Tumor Targeting and Inhibition, ACS Appl. Polym. Mater. 2022, 4, 2, 1368-1376. (Pdf)

2. Ziqi Zhang, Yue Cao, Qiong Yuan, Chenghui Liu, Xinrui Duan* and Yanli Tang*, Multifunctional fluorescent probe for effective visualization, inhibition, and detoxification of β-amyloid aggregation via covalent binding, Chem. Commun. 2022, 2022, 58, 3957. (Pdf)

3. Mingxiu Wang, Feng Zhang, Cai-Qi Wang, Nan Yin, Yuting Wang, Guixin Qin, Qingling Xu*, Jianhua Gong*, Huizhen Liu*, and Xinrui Duan*, Target-Binding Accelerated Response for Sensitive Detection of Basal H2O2 in Tumor Cells and Tissues via a Dual-Functional Fluorescence Probe, Anal. Chem. 2022, 94, 15, 5962-5969.

4. Yukun Li, Beibei Zhu, Wanying Han, Wei Tang, Xinrui Duan*, A bright chemiluminescence conjugated polymer–mesoporous silica nanoprobe for imaging of colonic tumors in vivo,Analyst, 2022, 147, 2060-2067.(Pdf)

5. Tianjiao Meng, Wenbo Ma, Mengyue Fan, Wei Tang, and Xinrui Duan* Enhancing the Contrast of Tumor Imaging for Image-Guided Surgery Using a Tumor-Targeting Probiotic with the Continuous Expression of a Biomarker, Anal. Chem. 2022, DOI:10.1021/acs.analchem.2c01200.(Pdf)

2021

1. Yiqian Ren, Yao Qiang, Beibei Zhu, Wei Tang, Xinrui Duan* and Zhengping Li*, General Strategy for Bioluminescence Sensing of Peptidase Activity In Vivo Based on Tumor-Targeting Probiotic, Anal. Chem. 2021, 93, 4334−4341.(Pdf)

2. Chengcheng Huo, Wanying Han, Wei Tang, Xinrui Duan*, Stable SERS substrate based on highly reflective metal liquid-like films wrapped hydrogels for direct determination of small molecules in a high protein matrix, Talanta 2021, 234, 122678.(Pdf)

3. 段新瑞*，孟天姣，有机小分子荧光探针的设计及其在酶类肿瘤标志物检测中的研究进展，河北大学学报（自然科学版），2021, 41, 535-544（invited review).

2020

1. Yiqian Ren, Yao Qiang, Xinrui Duan* and Zhengping Li*, The distinct difference in azido sugar metabolic rate between neural stem cells and fibroblasts and its application for decontamination of chemically induced neural stem cells,Chem. Commun., 2020, 56, 2344-2347.(Pdf)

2019

1. Yiqian Ren, Yanru Li, Xinrui Duan*, Honghong Wang, Hui Wang, Zhengping Li*, One‐Step Quantitative Single Nucleotide Polymorphism (SNP) Diagnosis By Modified Loop‐Mediated Isothermal Amplification (mLAMP),ChemistrySelect, 2019, 4, 1423-1427.(Pdf)

2. Zengjin Li, Hui Guo, Fangyuan Xu, Wei Tang*, Xinrui Duan*, Sensitive monitoring of RNA transcription by optical amplifcation of cationic conjugated polymers Talanta, 2019, 203, 314-321.(Pdf)

3. Fangyuan Xu, Mengyue Fan, Saisai Kang, XinruiDuan*, A genetically encoded fluorescent biosensor for detecting nitroreductase activity in living cancer cells Analytica Chimica Acta 2019, 1088, 131-136. (Pdf)

2018

1. Fangyuan Xu, Wei Tang, Saisai Kang, Jinsheng Song,*Xinrui Duan*, A highly sensitive and photo-stable fluorescent probe for endogenous intracellular H₂O₂ imaging in live cancer cells Dyes and Pigments 2018, 153, 61-66. (Pdf)

2. Beibei Zhu, Wei Tang, Yiqian Ren, Xinrui Duan*, Chemiluminescence of conjugated-polymer nanoparticles by direct oxidation with hypochlorite, Anal. Chem. 2018, 90, 13714-13722. (Pdf)

3. Hui Guo,‡ Mengyue Fan,‡ Zengjin Li, Wei Tang* and Xinrui Duan*, Ratiometric RNA aptamer/fluorophore complex for RNA synthesis detection, Anal. Methods, 2018, 10, 5629-5633. (Pdf)

4. Hui Guo, Wei Tang, Xinrui Duan*, A selective and sensitive azido near-infrared fluorescent probe for tris(2-carboxyethyl) phosphine quantitative detection and its application for E. coli determination, Anal. Methods, 2018, 10, 5823-5826. (Pdf)

2017

1. Hui Wang, Honghong Wang,Xinrui Duan*, Chenghui Liu, Zhengping Li*, Digital quantitative analysis of microRNA in single cell based on ligationdepended polymerase colony (Polony), Biosens. Bioelectron. 2017, 95, 146-151.(Pdf)

2. Hui Wang, Honghong Wang,Xinrui Duan*, Xiangdong Wang, Yuanyuan Sun, Zhengping Li*, Sensitive detection of mRNA by using specific cleavage-mediatedisothermal exponential amplification reaction, Sensors and Actuators B, 2017, 252, 215-221.(Pdf)

3. Honghong Wang, Hui Wang,Xinrui Duan*,Yuanyuan Sun, Xiangdong Wang, Zhengping Li*, Highly sensitive and multiplexed quantification of mRNA splice variants by the direct ligation of DNA probes at the exon junction and universal PCR amplification, Chem. Sci. 2017, 8, 3635-3640.(Pdf)

4. Mengyue Fan, Yuanyuan Zhou, Yijing Guo, Jinsheng Song*,Xinrui Duan*, Bright red fluorescent conjugated polymer nanoparticles with dibenzopyran as electron donor for cell imaging, Anal. Methods 2017, 9, 3255–3259.(Pdf)

2016

1. Yanru Li, Lingbo Sun, Hongxia Fu,Xinrui Duan*, Facile fabrication of a 3D electrospun fibrous mat by ice-templating for a tumor spheroid culture, Polym. Chem. 2016, 7, 6805-6811.(Pdf)

2. Lingbo Sun, Hongxia Fu, Yanru Li,Xinrui Duan*; Zhengping Li*, Rapid recognition and isolation of live colon cancer stem cells by using metabolic labeling of azido sugar and magnetic beads, Anal. Chem. 2016, 88, 3953–3958.(Pdf)

2015

1. Hongxia Fu, Yanru Li, Lingbo Sun, Pan He,Xinrui Duan*,Ratiometric fluorescence azide-alkyne cycloaddition for live mammalian cell imaging, Anal. Chem. 2015, 87，11332-11336.(Pdf)

2. Tianyu Wang, Hongxia Fu,Xinrui Duan*and Zhengping Li* An electrospun micro/nanofibrous mesh based nontoxic sensor for optical detection of high humidity, Anal. Methods 2015, 7, 3676.(Pdf)

3. Hongxia Fu andXinrui Duan*,Highly sensitive and colorimetric detection of hydrogen sulphide by in situ formation of Ag2S@Ag nanoparticles in polyelectrolyte multilayer film RSC advances 2015, 5, 3508.(Pdf)

2013 & Before:

1.Xinrui Duan, Honglin Li, Hexin Chen*, Qian Wang*, Discrimination of colon cancer stem cells using noncanonical amino acid, Chem. Comm. 2012,48, 9035-9037.

2.Xinrui Duan, Libing Liu, Xuli Feng, Shu Wang*, Assemblies of Conjugated Polyelectrolytes with Proteins for Controlled Protein Photoinactivation, Adv. Mater. 2010, 22, 1602.

3.Xinrui Duan, Wei Yue, Libing Liu, Zhengping Li, Yuliang Li, Fuchu He, Daoben Zhu, Gangqiao Zhou*, Shu Wang*, Single nucleotide polymorphism (SNP) genotyping using cationic conjugated polymers in homogeneous solution, Nat. Protoc. 2009, 4, 984-991.

4.Xinrui Duan, Zhengping Li*, Fang He, Shu Wang*, A sensitive and Homogeneous SNP Detection Using Cationic Conjugated Polymers, J. Am. Chem. Soc. 2007, 129, 4154-4155.